Preferred Label : tissue distribution;
MeSH definition : Accumulation of a drug or chemical substance in various organs (including those not
relevant to its pharmacologic or therapeutic action). This distribution depends on
the blood flow or perfusion rate of the organ, the ability of the drug to penetrate
organ membranes, tissue specificity, protein binding. The distribution is usually
expressed as tissue to plasma ratios.;
MeSH synonym : tissue distributions; distributions, tissue; distribution, tissue;
MeSH annotation : distrib of drugs or chem in organs & tissues; GEN only: not a substitute for organ
/metab or organ /chem; never IM; coord NIM with substance /pharmacokin (IM) or /metab
(IM); general only: not a substitute for organ /metab or organ /chem; usually NIM; coordinate
with substance /pharmacokin or /metab;
Origin ID : D014018;
UMLS CUI : C0040287;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
Accumulation of a drug or chemical substance in various organs (including those not
relevant to its pharmacologic or therapeutic action). This distribution depends on
the blood flow or perfusion rate of the organ, the ability of the drug to penetrate
organ membranes, tissue specificity, protein binding. The distribution is usually
expressed as tissue to plasma ratios.
Information Update - New safety information on injectable gadolinium-based contrast
agents used in MRI scans
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2017/61676a-fra.php
2017
false
false
false
Canada
French
English
pharmacovigilance note
magnetic resonance imaging
contrast media
gadolinium
cerebrum
tissue distribution
gadolinium
risk assessment
injections
product surveillance, postmarketing
magnetic resonance imaging contrast media
canada
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