Preferred Label : shwartzman phenomenon;
MeSH definition : Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction,
an initial local (intradermal) or general (intravenous) injection of a priming endotoxin
(ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent)
24 h later. The acute inflammation damages the small blood vessels. The following
intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman
phenomenon can also occur in other species with a single injection of a provoking
agent, and during infections or pregnancy. Its susceptibility depends on the status
of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.;
MeSH synonym : schwartzman reaction; shwartzman reaction; phenomenon, shwartzman; schwartzman phenomenon; phenomenon, schwartzman; schwartzman reactions;
CISMeF synonym : Shwartzman;
Wikipedia link : https://en.wikipedia.org/wiki/Shwartzman phenomenon;
Origin ID : D012790;
UMLS CUI : C0037018;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction,
an initial local (intradermal) or general (intravenous) injection of a priming endotoxin
(ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent)
24 h later. The acute inflammation damages the small blood vessels. The following
intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman
phenomenon can also occur in other species with a single injection of a provoking
agent, and during infections or pregnancy. Its susceptibility depends on the status
of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.
