Preferred Label : Degrons;
MeSH definition : Minimal elements within a protein that are sufficient for recognition and degradation
by a proteolytic apparatus. Inherent degrons are comprised of short linear amino acid
sequences and secondary protein structural features that increase the affinity to
E3 LIGASE; and are involved in regulating the specificity and timing of PROTEIN DEGRADATION.
Acquired degrons are mostly transient and conferred by post-translational modifications
of specific amino acids within proteins. (From Mol Cell. 2016 Sep 15;63(6):1055-65);
MeSH synonym : Degron;
MeSH hyponym : C Degrons; C-Degron; Motif, PEST; Motifs, PEST; PEST Motifs; PEST Sequence; PEST Sequences; Sequence, PEST; Sequences, PEST; Box Motif, Destruction; Box Motifs, Destruction; Destruction Box Motifs; Motif, Destruction Box; Motifs, Destruction Box; D-Box Motif; D Box Motif; D-Box Motifs; Motif, D-Box; Motifs, D-Box; Destruction Boxes; Destruction Box; N Degrons; N-Degron;
Origin ID : D000097791;
UMLS CUI : C5828433;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
Minimal elements within a protein that are sufficient for recognition and degradation
by a proteolytic apparatus. Inherent degrons are comprised of short linear amino acid
sequences and secondary protein structural features that increase the affinity to
E3 LIGASE; and are involved in regulating the specificity and timing of PROTEIN DEGRADATION.
Acquired degrons are mostly transient and conferred by post-translational modifications
of specific amino acids within proteins. (From Mol Cell. 2016 Sep 15;63(6):1055-65)
