Proteolysis Targeting Chimera

Preferred Label : Proteolysis Targeting Chimera;

MeSH definition : Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.;

MeSH synonym : PROTACs; PROTAC Proteolysis Targeting Chimera; Proteolysis Targeting Chimeras; Chimeras, Proteolysis Targeting; Targeting Chimeras, Proteolysis;

MeSH hyponym : IAP Based PROTACs; VHL Based PROTACs; MDM2 Protein Based PROTACs; Phospho Dependent PROTACs; PhosphoPROTACs; Cereblon Based Small Molecule Compounds;

Details

Origin ID

D000094243;

UMLS CUI

C5690794;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
Record concept(s)
- Cereblon-Based Small-Molecule Compounds [MeSH concept]
- IAP-Based PROTACs [MeSH concept]
- MDM2 Protein-Based PROTACs [MeSH concept]
- Phospho-Dependent PROTACs [MeSH concept]
- Proteolysis Targeting Chimera [MeSH concept]
- VHL-Based PROTACs [MeSH concept]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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