Preferred Label : Biomolecular Condensates;
MeSH definition : Membraneless intracellular compartments formed through liquid-liquid phase separation
from the surrounding CYTOPLASM or nucleoplasm or by the concentration of proteins
and nucleic acids into droplets as they aggregate on static cellular structures such
as CELL MEMBRANES. Examples include CELL NUCLEOLI; STRESS GRANULES; PARASPECKLES;
HISTONE LOCUS BODIES; and POSTSYNAPTIC DENSITIES.;
Définition CISMeF : Biomolecular condensates are a class of non-membrane bounded organelles and organelle
subdomains, specified by physical concepts that date back a long way. As with other
organelles, biomolecular condensates are specialized subunits of the cell. However,
unlike many organelles, biomolecular condensate composition is not controlled by a
bounding membrane. Instead they can form through a range of different processes, the
most well-known of which is phase separation of proteins, RNA and other biopolymers
into either colloidal emulsions, liquid crystals, solid crystals or aggregates within
cells (source https://en.wikipedia.org/wiki/Biomolecular_condensate).;
MeSH synonym : Biomolecular Condensate; Condensate, Biomolecular; Condensates, Biomolecular; Membraneless Organelles; Membraneless Organelle; Organelle, Membraneless; Organelles, Membraneless;
Origin ID : D000091582;
UMLS CUI : C5544475;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
Membraneless intracellular compartments formed through liquid-liquid phase separation
from the surrounding CYTOPLASM or nucleoplasm or by the concentration of proteins
and nucleic acids into droplets as they aggregate on static cellular structures such
as CELL MEMBRANES. Examples include CELL NUCLEOLI; STRESS GRANULES; PARASPECKLES;
HISTONE LOCUS BODIES; and POSTSYNAPTIC DENSITIES.
Biomolecular condensates are a class of non-membrane bounded organelles and organelle
subdomains, specified by physical concepts that date back a long way. As with other
organelles, biomolecular condensates are specialized subunits of the cell. However,
unlike many organelles, biomolecular condensate composition is not controlled by a
bounding membrane. Instead they can form through a range of different processes, the
most well-known of which is phase separation of proteins, RNA and other biopolymers
into either colloidal emulsions, liquid crystals, solid crystals or aggregates within
cells (source https://en.wikipedia.org/wiki/Biomolecular_condensate).
