Preferred Label : mu-Crystallins;
MeSH definition : A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS
and in neural tissue, muscle, and kidney in humans. It is not a structural protein
accounting for the transparency of the human lens unlike other crystallins but instead
plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase
which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE
KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins
are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.;
MeSH synonym : mu Crystallins; NADP-Regulated Thyroid Hormone Binding Protein; NADP Regulated Thyroid Hormone Binding Protein; CRYM Protein; Protein, CRYM; THBP Protein; Protein, THBP; Crystallin mu; mu, Crystallin; Ketimine Reductase mu-Crystallin; Ketimine Reductase mu Crystallin; Reductase mu-Crystallin, Ketimine; mu-Crystallin, Ketimine Reductase;
MeSH Related Number : 147681-64-9;
UNII : EC 1.5.1.25;
Origin ID : D000090803;
UMLS CUI : C0173278;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS
and in neural tissue, muscle, and kidney in humans. It is not a structural protein
accounting for the transparency of the human lens unlike other crystallins but instead
plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase
which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE
KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins
are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.
