Preferred Label : Phase Variation;
MeSH definition : An adaptive mechanism used by microbes to avoid detection by the host or adapt to
changes in environment by randomly and rapidly switch on and off of a gene by various
mechanisms. between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS
arises though rapid reversible mutations in the glpK gene through phase variation.; An adaptive mechanism used by microbes to avoid detection by the host or adapt to
changes in environment by randomly and rapidly switch on and off of a gene by various
mechanisms between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS
arises through rapid reversible mutations in the glpK gene through phase variation.;
Définition CISMeF : In biology, phase variation is a method for dealing with rapidly varying environments
without requiring random mutation. It involves the variation of protein expression,
frequently in an on-off fashion, within different parts of a bacterial population.
As such the phenotype can switch at frequencies that are much higher (sometimes 1%)
than classical mutation rates. Phase variation contributes to virulence by generating
heterogeneity. Although it has been most commonly studied in the context of immune
evasion, it is observed in many other areas as well and is employed by various types
of bacteria, including Salmonella species (source https://en.wikipedia.org/wiki/Phase_variation).;
MeSH synonym : Phase Variations; Variation, Phase;
Related MeSH term : Phasevarion; Phase-Variable Regulons; Phase Variable Regulons; Phase-Variable Regulon; Regulon, Phase-Variable;
Origin ID : D000090502;
UMLS CUI : C5544526;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
An adaptive mechanism used by microbes to avoid detection by the host or adapt to
changes in environment by randomly and rapidly switch on and off of a gene by various
mechanisms. between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS
arises though rapid reversible mutations in the glpK gene through phase variation.
An adaptive mechanism used by microbes to avoid detection by the host or adapt to
changes in environment by randomly and rapidly switch on and off of a gene by various
mechanisms between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS
arises through rapid reversible mutations in the glpK gene through phase variation.
In biology, phase variation is a method for dealing with rapidly varying environments
without requiring random mutation. It involves the variation of protein expression,
frequently in an on-off fashion, within different parts of a bacterial population.
As such the phenotype can switch at frequencies that are much higher (sometimes 1%)
than classical mutation rates. Phase variation contributes to virulence by generating
heterogeneity. Although it has been most commonly studied in the context of immune
evasion, it is observed in many other areas as well and is employed by various types
of bacteria, including Salmonella species (source https://en.wikipedia.org/wiki/Phase_variation).
