Preferred Label : Nuclear Bodies;
MeSH definition : Dynamic intranucleoplasmic membraneless structures which concentrate various nuclear
factors. Nuclear bodies exchange components with NUCLEOPLASM and participate in various
RNA metabolisms unlike nuclear INCLUSION BODIES which aggregate most often foreign
or inactive pathological biomolecules.;
Définition CISMeF : Nuclear bodies (also known as nuclear domains, or nuclear dots) are membraneless structures
found in the cell nuclei of eukaryotic cells. Nuclear bodies include Cajal bodies,
the nucleolus, and promyelocytic leukemia protein (PML) nuclear bodies (also called
PML oncogenic dots). Nuclear bodies also include ND10s. ND stands for nuclear domain,
and 10 refers to the number of dots seen. Nuclear bodies were first seen as prominent
interchromatin structures in the nuclei of malignant or hyperstimulated animal cells
identified using anti-sp100 autoantibodies from primary biliary cirrhosis and subsequently
the promyelocytic leukemia (PML) factor, but appear also to be elevated in many autoimmune
and cancerous diseases. Nuclear dots are metabolically stable and resistant to nuclease
digestion and salt extraction. A nuclear body subtype is a clastosome suggested to
be a site of protein degradation (source https://en.wikipedia.org/wiki/Nuclear_bodies),;
MeSH synonym : Nuclear Body;
MeSH Hyperonym : Condensate, Transcriptional; Transcriptional Condensate; Transcriptional Droplets; Droplet, Transcriptional; Transcriptional Droplet;
MeSH hyponym : Body, Histone Locus; Histone Locus Body; Nuclear Dicing Body; Dicing Body, Nuclear; Sphere Organelle; Organelle, Sphere; Body, Cleavage; Cleavage Body; Granule, Interchromatin; Interchromatin Granule;
Origin ID : D000088202;
UMLS CUI : C0230595;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
Dynamic intranucleoplasmic membraneless structures which concentrate various nuclear
factors. Nuclear bodies exchange components with NUCLEOPLASM and participate in various
RNA metabolisms unlike nuclear INCLUSION BODIES which aggregate most often foreign
or inactive pathological biomolecules.
Nuclear bodies (also known as nuclear domains, or nuclear dots) are membraneless structures
found in the cell nuclei of eukaryotic cells. Nuclear bodies include Cajal bodies,
the nucleolus, and promyelocytic leukemia protein (PML) nuclear bodies (also called
PML oncogenic dots). Nuclear bodies also include ND10s. ND stands for nuclear domain,
and 10 refers to the number of dots seen. Nuclear bodies were first seen as prominent
interchromatin structures in the nuclei of malignant or hyperstimulated animal cells
identified using anti-sp100 autoantibodies from primary biliary cirrhosis and subsequently
the promyelocytic leukemia (PML) factor, but appear also to be elevated in many autoimmune
and cancerous diseases. Nuclear dots are metabolically stable and resistant to nuclease
digestion and salt extraction. A nuclear body subtype is a clastosome suggested to
be a site of protein degradation (source https://en.wikipedia.org/wiki/Nuclear_bodies),
