Preferred Label : Processing Bodies;
MeSH definition : Cytoplasmic RNP granules constitutively found in eukaryotic cells. Various proteins
related to RNA regulation including RNA decay are found in P-bodies. P-bodies and
STRESS GRANULES both sequester inactive mRNPs via different pathways. In P-bodies
mRNAs from the stalled translational machinery are deadenylated and condensed for
sequestration.;
Définition CISMeF : P-bodies, or processing bodies are distinct foci formed by phase separation within
the cytoplasm of the eukaryotic cell consisting of many enzymes involved in mRNA turnover.
P-bodies are highly conserved structures and have been observed in somatic cells originating
from vertebrates and invertebrates, plants and yeast. To date, P-bodies have been
demonstrated to play fundamental roles in general mRNA decay, nonsense-mediated mRNA
decay, adenylate-uridylate-rich element mediated mRNA decay, and microRNA (miRNA)
induced mRNA silencing.[1] Not all mRNAs which enter P-bodies are degraded, as it
has been demonstrated that some mRNAs can exit P-bodies and re-initiate translation.[2][3]
Purification and sequencing of the mRNA from purified processing bodies showed that
these mRNAs are largely translationally repressed upstream of translation initiation
and are protected from 5' mRNA decay (source https://en.wikipedia.org/wiki/P-bodies).;
MeSH synonym : Processing Body; P Bodies; P Body; P-Bodies; P-Body;
Related MeSH term : GW Bodies; GW-Body; Glycine-Tryptophan Protein of 182 KDa Bodies; Glycine Tryptophan Protein of 182 KDa Bodies;
Origin ID : D000088142;
UMLS CUI : C1325596;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Record concept(s)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
Cytoplasmic RNP granules constitutively found in eukaryotic cells. Various proteins
related to RNA regulation including RNA decay are found in P-bodies. P-bodies and
STRESS GRANULES both sequester inactive mRNPs via different pathways. In P-bodies
mRNAs from the stalled translational machinery are deadenylated and condensed for
sequestration.
P-bodies, or processing bodies are distinct foci formed by phase separation within
the cytoplasm of the eukaryotic cell consisting of many enzymes involved in mRNA turnover.
P-bodies are highly conserved structures and have been observed in somatic cells originating
from vertebrates and invertebrates, plants and yeast. To date, P-bodies have been
demonstrated to play fundamental roles in general mRNA decay, nonsense-mediated mRNA
decay, adenylate-uridylate-rich element mediated mRNA decay, and microRNA (miRNA)
induced mRNA silencing.[1] Not all mRNAs which enter P-bodies are degraded, as it
has been demonstrated that some mRNAs can exit P-bodies and re-initiate translation.[2][3]
Purification and sequencing of the mRNA from purified processing bodies showed that
these mRNAs are largely translationally repressed upstream of translation initiation
and are protected from 5' mRNA decay (source https://en.wikipedia.org/wiki/P-bodies).
