Preferred Label : HaCaT Cells;
MeSH definition : A spontaneously transformed human epithelial cell line developed from a long-term
primary culture of human adult skin KERATINOCYTES. As it maintains an epidermal differentiation
capacity, it has been used as a model for keratinization studies. (From:J Cell Biol.
1988 Mar;106(3):761-71.);
Définition CISMeF : HaCaT is a spontaneously transformed aneuploid immortal keratinocyte cell line from
adult human skin,[1][2] widely used in scientific research.[3] HaCaT cells are utilized
for their high capacity to differentiate and proliferate in vitro.[4] Their use in
research allows for the characterization of human keratinocyte using a model that
is reproducible and addresses issues such as short culture lifespan and variations
between cell lines that would otherwise be encountered. These cells have allowed the
characterization of several processes, such as their utilization as a model system
for Vitamin D3 metabolism in the skin (source https://en.wikipedia.org/wiki/HaCaT).;
MeSH synonym : HaCaT Cell Line; Human Adult Low-Calcium High-Temperature Keratinocytes; Human Adult Low Calcium High Temperature Keratinocytes;
Origin ID : D000084282;
UMLS CUI : C5392106;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
- Cell [UMLS semantic type]
A spontaneously transformed human epithelial cell line developed from a long-term
primary culture of human adult skin KERATINOCYTES. As it maintains an epidermal differentiation
capacity, it has been used as a model for keratinization studies. (From:J Cell Biol.
1988 Mar;106(3):761-71.)
HaCaT is a spontaneously transformed aneuploid immortal keratinocyte cell line from
adult human skin,[1][2] widely used in scientific research.[3] HaCaT cells are utilized
for their high capacity to differentiate and proliferate in vitro.[4] Their use in
research allows for the characterization of human keratinocyte using a model that
is reproducible and addresses issues such as short culture lifespan and variations
between cell lines that would otherwise be encountered. These cells have allowed the
characterization of several processes, such as their utilization as a model system
for Vitamin D3 metabolism in the skin (source https://en.wikipedia.org/wiki/HaCaT).
