Protein-Arginine Deiminase Type 1

Preferred Label : Protein-Arginine Deiminase Type 1;

MeSH definition : A peptidylarginine deiminase isoenzyme. It is a post-translational modification enzyme that catalyzes the conversion of protein-bound ARGININE residues to CITRULLINE residues in a CALCIUM ion-dependent manner. It functions within the epidermis, targeting INTERMEDIATE FILAMENTS; KERATINS; and filaggrin for CITRULLINATION to promote epidermal cornification.;

MeSH synonym : Peptidyl Arginine Deiminase Type I; Protein Arginine Deiminase Type 1; Protein Arginine Deiminase Type I; PAD Type I; Peptidylarginine Deiminase I; Protein Arginine Deiminase 1; Peptidylarginine Deiminase Type 1; PADI1 Protein; Peptidylarginine Deiminase Type I; Peptidyl Arginine Deiminase Type 1; Protein-Arginine Deiminase Type I;

UNII : EC 3.5.3.15;

Details

Origin ID

D000080062;

UMLS CUI

C4760631;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
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- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
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- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
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- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- Protein-Arginine Deiminase Type 1 [MeSH concept]
See also
- Citrullination [MeSH Descriptor]
See also inter- (CISMeF)
- Peptidylarginine deiminase, type I [OMIM gene]
- peptidyl arginine deiminase 1 [HGNC gene]
Semantic type(s)
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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