Preferred Label : MutS Proteins;
MeSH definition : DNA repair proteins that include the bacterial MutS DNA mismatch-binding protein and
its eukaryotic homologs that function in DNA MISMATCH REPAIR and recombination of
DNA during MEIOSIS. MutS has a conserved mismatch recognition domain characterized
by GxFxE, or similar AMINO ACID MOTIFS that also occur in eukaryotic homologs such
as MSH1, MSH6, and MSH8. All MutS proteins also contain a highly-conserved ATP-binding
domain and most have weak ATPase activity.;
MeSH synonym : MutS Protein; Protein, MutS;
DeCS synonym : MutS Homolog Proteins;
MeSH hyponym : Homolog Proteins, MutS; Proteins, MutS Homolog; MutS Homologs; MutS Homolog Protein; Homolog Protein, MutS; Protein, MutS Homolog; MutS Homolog; Homolog, MutS;
Registry Number MeSH : EC 3.6.1.3;
UNII : EC 3.6.1.3;
Origin ID : D000074080;
UMLS CUI : C4505189;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Semantic type(s)
DNA repair proteins that include the bacterial MutS DNA mismatch-binding protein and
its eukaryotic homologs that function in DNA MISMATCH REPAIR and recombination of
DNA during MEIOSIS. MutS has a conserved mismatch recognition domain characterized
by GxFxE, or similar AMINO ACID MOTIFS that also occur in eukaryotic homologs such
as MSH1, MSH6, and MSH8. All MutS proteins also contain a highly-conserved ATP-binding
domain and most have weak ATPase activity.
