Cholesterol 24-Hydroxylase

Preferred Label : Cholesterol 24-Hydroxylase;

MeSH definition : A steroid hydroxylase that functions in CHOLESTEROL homeostasis in the brain. It converts cholesterol into 24S-hydroxycholesterol, which is transported over the BLOOD-BRAIN BARRIER more rapidly than unmetabolized cholesterol.;

MeSH synonym : Cholesterol 24 Hydroxylase; Brain-Specific 24S-Hydroxylase; Brain Specific 24S Hydroxylase;

DeCS synonym : Cytochrome P450 46A1; Cholestane Tetrol 24-Hydroxylase;

MeSH hyponym : Cholestane Tetrol 24 Hydroxylase; 5(beta)-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol-24S-hydroxylase; CYP46A1;

Registry Number MeSH : EC 1.14.14.25;

UNII : EC 1.14.14.25;

Details

Origin ID

D000072556;

UMLS CUI

C0769789;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Cytochrome p450, family 46, subfamily a, polypeptide 1 [OMIM gene]
- cholesterol 24-hydroxylase activity [GO term]
Record concept(s)
- Cytochrome P450 46A1 [MeSH concept]
- cholestane tetrol 24-hydroxylase [MeSH concept]
- cholesterol 24-hydroxylase [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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