Preferred Label : Posoleucel;
NCIt synonyms : Allogeneic EBV/CMV/AdV/HHV6/BKV/JCV-specific CTLs ALVR105; Allogeneic Multi-virus-specific CTLs ALVR105; VSTs ALVR105;
NCIt definition : A population of closely human leukocyte antigen (HLA)-matched, off-the-shelf (OTS),
donor-derived cytotoxic T lymphocytes (CTLs) that are specifically reactive towards
six viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (AdV), human
herpesvirus 6 (HHV6; HHV-6), human polyomavirus type I (BKV) and human polyomavirus
type II (JC virus; JCV), with potential antiviral activity. Upon infusion into allogeneic
hematopoietic stem cell transplant (HSCT) recipients and immunocompromised patients,
posoleucel provides virus-specific cellular immunity and causes specific anti-viral
effects against active viral infections. This may prevent EBV, CMV, AdV, HHV6, BKV
and JCV reactivation and infection, and inhibits viral-associated diseases.;
UNII : CH357NR3E3;
Drug name : Viralym-M;
Molecule name : ALVR-105; ALVR 105;
NCI Metathesaurus CUI : CL1406864;
Origin ID : C172802;
UMLS CUI : C5706677;
Semantic type(s)
- Cell [UMLS semantic type]
concept_is_in_subset