Autologous Bone Marrow-derived CD34/CXCR4-positive Stem Cells AMR-001 - CISMeF
Autologous Bone Marrow-derived CD34/CXCR4-positive Stem Cells AMR-001NCIt concept
Preferred Label : Autologous Bone Marrow-derived CD34/CXCR4-positive Stem Cells AMR-001;
NCIt definition : A cell-based product containing autologous bone marrow derived CD34 positive and C-X-C
chemokine receptor type 4 (CXCR4) positive stem cells with potential antiapoptotic
and proangiogenic activities. Upon intracoronary infusion after a myocardial infarction
(MI), autologous bone marrow-derived CD34/CXCR4-positive stem cells may preserve cardiac
muscle cells and prevent apoptosis; thus improving myocardial perfusion. CD34/CXCR4-positive
stem cells are naturally mobilized upon cell injury through signaling by hypoxia inducing
factor (HIF), which is secreted in response to hypoxia. In turn, HIF induces the synthesis
of stromal-derived factor 1 (SDF-1) and vascular endothelial growth factor (VEGF)
which mobilize CD34/CXCR4 positive stem cells; CXCR4 is the receptor for stromal-derived
factor 1 (SDF-1).;