NCIt definition : A dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes
serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity,
this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic
and mesocortical areas of the brain leading to decreased psychotic effects, such as
hallucinations and delusions. In addition, quetiapine also binds to other alpha-1,
alpha-2 adrenergic and histamine H1 receptors.;