Histone H3 - CISMeF

Preferred Label : Histone H3;

NCIt synonyms : Histone-H3;

NCIt related terms : H3;

NCIt definition : Histone H3 is a core subunit of the eukaryotic nucleosome complex. Histones are basic nuclear proteins responsible for the nucleosome structure of chromatin. Repeating nucleosome units contain two molecules each of Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. (NCI);

Alternative definition : CDISC: An antigen in the core histone family and a subunit of the nucleosome complex, with a designation of H3. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases systemic lupus erythematosus and rheumatoid arthritis.;

Details

Origin ID

C16685;

UMLS CUI

C0019647;

Automatic exact mappings (from CISMeF team)
- Relaxin 3 [OMIM gene]
- fibroblast growth factor receptor 1 [ORDO Gene]
- histones [MeSH Descriptor]
Currated CISMeF NLP mapping
- Histone H3 [FMA entity]
- Histone H3 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Histone H3 [FMA entity]
- Histone H3 [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Pediatric Oncology Target Genes/Proteins Terminology [NCIt concept]
gene_encodes_gene_product
- Histone Gene [NCIt concept]
- Histone H3 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Chromatin [NCIt concept]
- Nucleosome [NCIt concept]
- Nucleosome Core Particle [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_gene_product_variant
- H3 G35R Variant [NCIt concept]
- H3 G35V Variant [NCIt concept]
- H3 G35X Variant [NCIt concept]
- H3 K27I Variant [NCIt concept]
- H3 K27M Variant [NCIt concept]
- H3 K28X Variant [NCIt concept]
- H3 Protein Variant [NCIt concept]
- H3.1 K27M Variant [NCIt concept]
- H3.3 G35X Variant [NCIt concept]
- H3.3 K27I Variant [NCIt concept]
- H3.3 K27M Variant [NCIt concept]
- H3.3 NP_002098.1:p.G35L [NCIt concept]
- H3.3 NP_002098.1:p.G35R [NCIt concept]
- H3.3 NP_002098.1:p.G35V [NCIt concept]
- H3.3 NP_002098.1:p.G35W [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Chromatin Structural Process [NCIt concept]
- Gene Regulation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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