Preferred Label : 2-Ethylhydrazide;
NCIt synonyms : 2-Ethylhydrazide;
NCIt definition : A podophyllic acid derivative of podophyllotoxin, a substance extracted from the mandrake
root Podophyllum peltatum. Possessing potent antineoplastic properties, 2-ethylhydrazide
binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules,
resulting in the accumulation of single- or double-strand DNA breaks, the inhibition
of DNA replication and transcription, and apoptotic cell death.;
Origin ID : C1165;
UMLS CUI : C1521024;
Semantic type(s)
- concept_is_in_subset
