Preferred Label : base of crypt of Lieberkuhn;
Uberon definition : The basal portion (further from lumen) of an intestinal crypt. Contains multipotent
stem cells. Stem cells in the crypts divide to form daughter cells. One daughter cell
from each stem cell division is retained as a stem cell. The other becomes committed
to differentiate along one of four pathways to become an enterocyte, enteroendocrine
cell, goblet cell or Paneth cell.;
Uberon synonym : base of intestinal gland; basal portion of intestinal gland; base part of epithelium of intestinal gland;
Uberon Taxon note : Clearly defined prolifieration zones found in mammals. Not observed in agnathostomes,
larval amphibians. Described in advanced species of fish and adult amphibians.;
Origin ID : 0013739;
continuous with
The basal portion (further from lumen) of an intestinal crypt. Contains multipotent
stem cells. Stem cells in the crypts divide to form daughter cells. One daughter cell
from each stem cell division is retained as a stem cell. The other becomes committed
to differentiate along one of four pathways to become an enterocyte, enteroendocrine
cell, goblet cell or Paneth cell.
