Preferred Label : distal segment of digit;
Uberon definition : A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal
joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins,
and includes the distal bone with associated marrow cavity and haematopoietic cells,
ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and
luminal secreting cells and associated neurons for innervation, dermis with resident
melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis
with hair follicles, a nail organ composed of six specific parts (the root, nail bed,
nail plate, eponychium (cuticle), perionychium and hyponychium).;
Uberon synonym : digit tip; distal digit segment; tip of digit;
Uberon Development note : Newborn and adult mice are able to regrow forelimb (finger) and hindlimb (toe) digit
tips after their amputation through the distal interphalangeal joint. Regeneration
of the digit tip involves the integrated regrowth of multiple tissues within 2-3 months,
reaching an external morphology that is cosmetically and functionally similar to normal
digits. Most importantly, regeneration of the mouse distal digit shares morphological
similarities with clinical cases documenting regrowth of missing distal portions of
fingers in both children and adults;
Origin ID : 0009551;
has part
- part of
A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal
joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins,
and includes the distal bone with associated marrow cavity and haematopoietic cells,
ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and
luminal secreting cells and associated neurons for innervation, dermis with resident
melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis
with hair follicles, a nail organ composed of six specific parts (the root, nail bed,
nail plate, eponychium (cuticle), perionychium and hyponychium).
