" /> mammary gland myoepithelium - CISMeF





Preferred Label : mammary gland myoepithelium;

Uberon definition : the outer cell layer of the mammary gland epithelium bilayer which is located basal to the luminal (secretory) cells and adjacent to the basement membrane.;

Uberon synonym : myo-epithelium of lactiferous duct; lactiferous ductal myo-epithelium; myoepithelium of lactiferous duct; mammary myoepithelium;

Uberon Structure note : The cells of this structure are specialized epithelial cells that express smooth muscle-specific contractile and cytoskeletal properties; during lactation, MECs contract in response to oxytocin to generate the contractile force required for milk ejection; MECs are involved in all developmental stages of mammary gland morphogenesis, modulating proliferation and differentiation of luminal cells; they take part in the formation of extracellular matrix, synthesizing its components and secreting proteinases and their inhibitors; in addition, MECs are regarded as natural cancer suppressors: they secrete suppressor proteins limiting cancer growth, invasiveness, and neoangiogenesis; MECs are markedly resistant to malignant transformation and they are able to suppress the transformation of neighboring luminal cells[MP];

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the outer cell layer of the mammary gland epithelium bilayer which is located basal to the luminal (secretory) cells and adjacent to the basement membrane.

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29/07/2025


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