Uberon definition : Portion of tissue that gives rise to the lens.;
Uberon related term : lens mass; immature lens; presumptive lens;
Uberon narrow term : hollow lens vesicle; solid lens vesicle;
Uberon Development note : the lens of zebrafish (and other teleosts) forms from delamination of cells from the
lens placode; thus, there is no formation of a hollow lens vesicle, in contrast to
the situation in mammals and birds (Glass and Dahm, 2004) [PMID:16496288] The lens
of the zebrafish forms by delamination of lens placodal cells and not through invagination.
This results in a solid spherical mass as opposed to a hollow lens vesicle. Detachment
of the solid lens vesicle of zebrafish at 24b26 hpf is accomplished in part by apoptosis,
similar to mammals;
Uberon Homology note : (...) an essentially similar sequence of events occurs during the embryonic development
of the vertebrate eye. The eye initially develops as a single median evagination of
the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic
vesicle grows towards the body surface, its proximal part narrows as the optic stalk,
and its distal part invaginates to form a two-layered optic cup. (...) The optic cup
induces the overlying surface ectoderm first to thicken as a lens placode and then
to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG];
Automatic exact mappings (from CISMeF team)