Preferred Label : pectoral appendage apical ectodermal ridge;
Uberon definition : An apical ectodermal ridge that is part of a pectoral appendage bud.;
Uberon related term : apical ectodermal ridge pectoral fin; apical fold pectoral fin; aer pectoral fin;
Uberon narrow term : apical ectodermal ridge pectoral fin bud; wing apical ectodermal ridge; wing AER; upper limb bud apical ectodermal ridge; apical ectodermal ridge forelimb; AER forelimb;
Uberon Homology note : Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively.
(...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening
at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum.
The AER is observed only transiently, and from 36 hpf onwards the cells of this region
form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped
ectodermal cells extending from the anterior to the posterior fin margin. Despite
the change in shape, the AF still carries out the same functions as the AER. Indeed,
although the AER receives its name from its characteristic shape, being composed of
a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse,
this independence of AER morphology from its function is also observed in tetrapods.
The AF also expresses similar molecular markers to the tetrapod AER, suggesting that
it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG];
Origin ID : 0005421;
develops from
- develops into
- part of
An apical ectodermal ridge that is part of a pectoral appendage bud.
