Preferred Label : circumventricular organ;
Uberon definition : Any of any of the secretory or sensory organs located in the brain region around or
in relation to the ventricular system that are characterized by extensive vasculature
and a lack of a normal blood brain barrier (BBB) and allow for the linkage between
the central nervous system and peripheral blood flow.;
Uberon synonym : CVO; circumventricular organ of neuraxis;
Uberon Structure note : CVOs contain neural tissue and are an integral part of neuroendocrine function; all
of the CVOs, besides the subcommissural organ, contain extensive vasculature and fenestrated
capillaries which leads to a leaky BBB at the site of the organs; the lack of a BBB
allows CVOs to act as an alternative route for peptides and hormones in the neural
tissue to the peripheral blood stream, while still protecting it from toxic substances;
Uberon Taxon note : All vertebrates possess at least 4 circumventricular organs (including the hypothalamus)
which can monitor the contents of the cerebrospinal fluid and secrete additional substances
into it. (Butler, 1996, p. 330);
Origin ID : 0005408;
Automatic exact mappings (from CISMeF team)
- Uberon cross reference
Any of any of the secretory or sensory organs located in the brain region around or
in relation to the ventricular system that are characterized by extensive vasculature
and a lack of a normal blood brain barrier (BBB) and allow for the linkage between
the central nervous system and peripheral blood flow.
