Preferred Label : mammary duct terminal end bud;
Uberon definition : A unique club-shaped epithelial structure that develops at the tip of the mammary
duct at the onset of puberty under the action of circulating hormones.;
Uberon Development note : TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of
a complex branching structure; this process of branching morphogenesis concludes at
10-12 weeks of age in mice, when TEBs have traversed the length of the fat pad and
a fully developed ductal tree has formed;
Uberon Structure note : terminal end buds (TEBs) consist of an outer layer of undifferentiated myoepithelial
progenitor cells ('cap cells'), and a multilayered inner core of luminal epithelial
cells ('body') fated to form the walls of the ductal lumen; both layers have high
rates of mitosis, consistent with a motile organ dedicated to ductal morphogenesis;
Origin ID : 0005313;
part of
A unique club-shaped epithelial structure that develops at the tip of the mammary
duct at the onset of puberty under the action of circulating hormones.
