Preferred Label : cortical subplate;
Uberon definition : The transient outer neural tube region that contains the first generated post-mitotic
neurons that receive synaptic input from thalamic axons and in turn project axons
to the developing cortical plate;
Uberon synonym : subplate zone; subplate; cerebral cortex subplate;
Uberon broad term : SP;
Uberon Development note : The transient fetal subplate zone, together with the marginal zone and the cortical
plate, represents the developmental anlage of the mammalian cerebral cortex. It serves
as a waiting compartment for growing cortical afferents; its cells are involved in
the establishment of pioneering cortical efferent projections and transient fetal
circuitry, and apparently have a number of other developmental roles. The subplate
zone is a phylogenetically recent structure and it is most developed in the human
brain. Subplate neurons are among the first generated neurons in the mammalian cerebral
cortex [1]. These neurons disappear during postnatal development and are important
in establishing the correct wiring [2][3] and functional maturation [4] of the cerebral
cortex. Subplate neurons appear to be selectively sensitive to injury (such as hypoxia)
which in humans are associated with motor and cognitive defects;
Origin ID : 0004035;
adjacent to
- develops from
The transient outer neural tube region that contains the first generated post-mitotic
neurons that receive synaptic input from thalamic axons and in turn project axons
to the developing cortical plate
