Preferred Label : prostate bud;
Uberon definition : A region of the fetal urogenital sinus epithelium destined to become the prostate[GO].;
Uberon synonym : prostate ductal progenitor; prostatic bud;
Uberon related term : prostate primordium; prostate gland bud;
Uberon Function note : AR activation releases instructive signals from UGM that acts on UGS epithelium (UGE)
to stimulate cell proliferation, form prostate ductal progenitors (prostatic buds),
and regulate cell adhesion dynamics to permit prostatic bud outgrowth. There are three
phases of prostatic budding: (1) the specification phase, when instructive developmental
cues define where buds will form in the UGS, (2) the initiation phase, when prostatic
buds begin to form, and (3) the elongation phase, when proliferation, cell adhesion,
and cell migration coordinate outgrowth of prostatic buds into UGM. Timing of prostatic
bud formation and the quantity and pattern of buds that are formed in the UGS are
strictly regulated [3, 4]. The position of prostatic buds as they emerge from the
UGS in utero determines the arrangement of prostate ducts in adulthood.[PMID:18977204];
Origin ID : 0003820;
develops from
- develops into
- has potential to develop into
A region of the fetal urogenital sinus epithelium destined to become the prostate[GO].
