Preferred Label : ciliary marginal zone;
Uberon definition : Region at the periphery of the retina where retinal stem cells are located. After
60 hpf, the CMZ is the source of most retinal growth.[Wehman et al, 2005];
Uberon synonym : retinal ciliary marginal zone; peripheral growth zone;
Uberon related term : CMZ; retinal proliferative zone; circumferential germinal zone;
Uberon Homology note : The retina of all vertebrates develops via similar mechanisms. Toward the end of retinal
histogenesis, proliferating progenitors and newly generated cells are confined to
peripheral regions of the retina. In fish and amphibians, this region is maintained
after embryonic development and becomes the CMZ (ciliary margin zone). A CMZ exists
in birds but compared to that of fish and amphibians this region produces much less
new retina as the globe of the eye expands postnatally. At least some of the molecular
mechanisms that regulate the addition of new cells in this zone appear to have been
conserved from fish to birds.[well established][VHOG];
Origin ID : 0003065;
part of
Region at the periphery of the retina where retinal stem cells are located. After
60 hpf, the CMZ is the source of most retinal growth.[Wehman et al, 2005]
