Preferred Label : blood island;
Uberon definition : Blood islands are structures in the developing embryo which lead to many different
parts of the circulatory system. They primarily derive from plexuses formed from angioblasts.
Within them, vacuoles appear through liquefaction of the central part of the syncytium
into plasma. The lumen of the blood vessels thus formed is probably intracellular.
The flattened cells at the periphery form the endothelium. The nucleated red blood
corpuscles develop either from small masses of the original angioblast left attached
to the inner wall of the lumen or directly from the flat endothelial cells. In either
case the syncytial mass thus formed projects from and is attached to the wall of the
vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates
within it. Later the cells on the surface round up, giving the mass a mulberry-like
appearance. Then the red blood cells break loose and are carried away in the plasma.
Such free blood cells continue to divide. Blood islands have been seen in the area
vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP,
unvetted].;
Uberon synonym : blood islands;
Uberon related term : caudal hematopoietic tissue; VBI; posterior blood island; ventral blood island; posterior ICM;
Uberon broad term : ventral lateral plate mesoderm;
Uberon Homology note : Small clusters of mesodermal cells called blood islands mark the embryonic debut of
the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive
hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood
islands (reference 2).[well established][VHOG];
Origin ID : 0003061;
UMLS CUI : C1511224;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Uberon cross reference
- develops from
- develops into
- has potential to develop into
Blood islands are structures in the developing embryo which lead to many different
parts of the circulatory system. They primarily derive from plexuses formed from angioblasts.
Within them, vacuoles appear through liquefaction of the central part of the syncytium
into plasma. The lumen of the blood vessels thus formed is probably intracellular.
The flattened cells at the periphery form the endothelium. The nucleated red blood
corpuscles develop either from small masses of the original angioblast left attached
to the inner wall of the lumen or directly from the flat endothelial cells. In either
case the syncytial mass thus formed projects from and is attached to the wall of the
vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates
within it. Later the cells on the surface round up, giving the mass a mulberry-like
appearance. Then the red blood cells break loose and are carried away in the plasma.
Such free blood cells continue to divide. Blood islands have been seen in the area
vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP,
unvetted].
