Preferred Label : central gray substance of midbrain;
Uberon definition : Periaqueductal gray (PAG; also called the 'central gray') is the gray matter located
around the cerebral aqueduct within the midbrain. It plays a role in the descending
modulation of pain and in defensive behaviour. The ascending pain and temperature
fibers of the spinothalamic tract also send information to the PAG via the spinomesencephalic
tract. The spinomesencephalic tract is so-named because the fibers originate in the
spine and terminate in the mesencephalon, another name for the midbrain, the part
of the brain in which the PAG resides. [WP,unvetted].;
Uberon synonym : periaqueductal gray; anulus of cerebral aqueduct; central (periaqueductal) gray; periaqueductal grey; periaqueductal gray matter; periaqueductal grey substance; midbrain periaqueductal grey; periaqueductal grey matter; periaqueductal gray of tegmentum;
Uberon related term : central grey substance of midbrain; pAG; central grey; periaquectuctal grey; central gray substance of the midbrain; central gray; periaqueductal gray, proper; central gray of the midbrain;
Uberon broad term : griseum centrale; CGMB; substantia grisea centralis;
Periaqueductal gray (PAG; also called the 'central gray') is the gray matter located
around the cerebral aqueduct within the midbrain. It plays a role in the descending
modulation of pain and in defensive behaviour. The ascending pain and temperature
fibers of the spinothalamic tract also send information to the PAG via the spinomesencephalic
tract. The spinomesencephalic tract is so-named because the fibers originate in the
spine and terminate in the mesencephalon, another name for the midbrain, the part
of the brain in which the PAG resides. [WP,unvetted].