Preferred Label : subiculum;
Uberon definition : Part of the hippocampal formation that is bounded by the entorhinal cortex and area
CA1. It is characterized on the CA1 border by an abrupt widening of the pyramidal
cell layer. A molecular layer is present that is continuous with that of CA1, although
the stratum radiatum is no longer present. The stratum oriens is also not present.
adapted from Paxinos, G. The rat central nervous system, 2nd ed, Academic Press, San
Diego, 1995, pg. 468);
Uberon synonym : subicular cortex; subiculum hippocampi;
Uberon related term : gyrus parahippocampalis; subiculum cornu ammonis;
Uberon Function note : The pyramidal neurons in the subiculum exhibit transitions between two modes of action
potential output: bursting and single spiking. The transitions between these two modes
is thought to be important for routing information out of the hippocampus. It is the
site responsible for ictal activity in some cases of human epilepsy. It has also been
implicated in working memory and drug addiction.[Wikipedia:Subiculum];
Origin ID : 0002191;
UMLS CUI : C0152316;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Uberon cross reference
- adjacent to
- part of
Part of the hippocampal formation that is bounded by the entorhinal cortex and area
CA1. It is characterized on the CA1 border by an abrupt widening of the pyramidal
cell layer. A molecular layer is present that is continuous with that of CA1, although
the stratum radiatum is no longer present. The stratum oriens is also not present.
adapted from Paxinos, G. The rat central nervous system, 2nd ed, Academic Press, San
Diego, 1995, pg. 468)
