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Preferred Label : spleen;

Uberon definition : the organ that functions to filter blood and to store red corpuscles and platelets;

Uberon Function note : It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells;

Uberon Homology note : With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG];

Uberon Taxon note : Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96);

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the organ that functions to filter blood and to store red corpuscles and platelets

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02/05/2025


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