Preferred Label : submandibular gland;
Uberon definition : Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands
composed of both serous and mucous secretory cells and situated beneath the mandible.;
Uberon synonym : mandibular gland; submandibular salivary gland; mandibular salivary gland;
Uberon related term : maxillary gland; submaxillary gland;
Uberon Development note : The submandibular is the first major salivary gland to develop in the embryo, followed
by the neighbouring sublingual and then the parotid.[PMID:17336109];
Uberon Homology note : The most common oral glands in mammals are the salivary glands. There are usually
three primary pairs of salivary glands, named for their approximate positions: mandibular
(submandibular or submaxillary), sublingual, and parotid.[well established][VHOG];
Uberon Taxon note : in mice, submandibular gland development initiates as a thickening of the oral epithelium;
around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural
crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at
E13.5, and branching morphogenesis occurs with continued proliferation, successive
rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14
the gland is highly branched (multi-lobed); functional differentiation, with the appearance
of proacinar cells and secretory products begins after E15 and continues to birth;
acinar differentiation continues postnatally with final differentiation of the granular
convoluted tubules at puberty[MGI:anna];
Uberon Terminology note : The term submandibular as used in humans, is incorrect due the difference in topography
of these structures[http://www.avdc.org];
Origin ID : 0001736;
UMLS CUI : C0038556;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Uberon cross reference
- develops from
- has part
- in lateral side of
- part of
Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands
composed of both serous and mucous secretory cells and situated beneath the mandible.
