Preferred Label : Receptor-Interacting Serine/Threonine-Protein Kinase 2;
NCIt synonyms : CARD-Containing IL-1 Beta Ice-Kinase; CARD-Containing Interleukin-1 Beta Converting Enzyme Associated Kinase; RIP2; RIPK2; RIP-Like Interacting CLARP Kinase; Receptor Interacting Protein 2; Receptor-Interacting Protein 2; RIP-Like-Interacting CLARP Kinase; EC 2.7.10.2; Tyrosine-Protein Kinase RIPK2; EC 2.7.11.1; Receptor-Interacting Serine/Threonine Protein Kinase 2; Receptor-Interacting Serine-Threonine Protein Kinase-2;
NCIt definition : Receptor-interacting serine/threonine-protein kinase 2 (540 aa, 61 kDa) is encoded
by the human RIPK2 gene. This protein is involved in protein phosphorylation, apoptosis
and inflammation.; Receptor-interacting serine/threonine-protein kinase 2 (540 aa, 61 kDa) is encoded
by the human RIPK2 gene. This protein is involved in protein phosphorylation, apoptosis
and inflammation.;
NCIt note : Receptor-interacting serine/threonine-protein kinase 2 also has tyrosine kinase activity.
(UniProt); Receptor-interacting serine/threonine-protein kinase 2 contains 1 CARD domain, activates
NF-Kappa B and potentiates apoptosis by activating pro-caspase-1 and pro-caspase-8.
RIPK2 binds to BIRC3/c-IAP1, BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5, and TRAF6 and binds
to CFLAR/CLARP and CASP1 via their CARD domains. RIPK2 may be a component of the TNFRSF1A
and TNRFSF5/CD40 receptor complexes.;
Origin ID : C29872;
UMLS CUI : C1447644;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_has_biochemical_function
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
