Preferred Label :
usual interstitial pneumonia; Definition :
Pathology.—UIP is a histologic pattern of pulmonary fibrosis characterized by temporal
and spatial heterogeneity, with established fibrosis and honeycombing interspersed
among normal lung. Fibroblastic foci with fibrotic destruction of lung architecture,
often with honeycombing, are the key findings (5). The fibrosis is initially concentrated
in the lung periphery. UIP is the pattern seen in idiopathic pulmonary fibrosis, but
can be encountered in diseases of known cause (eg, some cases of chronic hypersensitivity
pneumonitis). Radiographs and CT scans.—Honeycombing with a basal and subpleural distribution
(Fig 71) is regarded as pathognomonic (63,65), but not all cases of biopsy-proved
UIP have this distinctive CT pattern. [Fleischner Society]; RADLEX acronyms :
UIP; Image(s) :
RID5333Source :
Fleischner Society;
Origin ID : RID5333;
Automatic exact mappings (from CISMeF team)
Pathology.—UIP is a histologic pattern of pulmonary fibrosis characterized by temporal
and spatial heterogeneity, with established fibrosis and honeycombing interspersed
among normal lung. Fibroblastic foci with fibrotic destruction of lung architecture,
often with honeycombing, are the key findings (5). The fibrosis is initially concentrated
in the lung periphery. UIP is the pattern seen in idiopathic pulmonary fibrosis, but
can be encountered in diseases of known cause (eg, some cases of chronic hypersensitivity
pneumonitis). Radiographs and CT scans.—Honeycombing with a basal and subpleural distribution
(Fig 71) is regarded as pathognomonic (63,65), but not all cases of biopsy-proved
UIP have this distinctive CT pattern. [Fleischner Society]
