Preferred Label : Parkinson disease;
Definition : A progressive, degenerative neurologic disease characterized by a tremor that is maximal
at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture,
slowness of voluntary movements, and a masklike facial expression. Pathologic features
include loss of melanin containing neurons in the substantia nigra and other pigmented
nuclei of the brainstem. lewy bodies are present in the substantia nigra and locus
coeruleus but may also be found in a related condition (lewy body disease, diffuse)
characterized by dementia in combination with varying degrees of parkinsonism. (Adams
et al., Principles of Neurology, 6th ed, p1059, pp1067-75) [MeSH];
UMLS CUI (RADLEX) : C0030567;
Origin ID : RID5163;
UMLS CUI : C0030567;
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
Semantic type(s)
UMLS correspondences (same concept)
A progressive, degenerative neurologic disease characterized by a tremor that is maximal
at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture,
slowness of voluntary movements, and a masklike facial expression. Pathologic features
include loss of melanin containing neurons in the substantia nigra and other pigmented
nuclei of the brainstem. lewy bodies are present in the substantia nigra and locus
coeruleus but may also be found in a related condition (lewy body disease, diffuse)
characterized by dementia in combination with varying degrees of parkinsonism. (Adams
et al., Principles of Neurology, 6th ed, p1059, pp1067-75) [MeSH]