Preferred Label : retinoblastoma;
Definition : A malignant tumor arising from the nuclear layer of the retina that is the most common
primary tumor of the eye in children. The tumor tends to occur in early childhood
or infancy and may be present at birth. The majority are sporadic, but the condition
may be transmitted as an autosomal dominant trait. Histologic features include dense
cellularity, small round polygonal cells, and areas of calcification and necrosis.
An abnormal pupil reflex (leukokoria); nystagmus, pathologic; strabismus; and visual
loss represent common clinical characteristics of this condition. (From DeVita et
al., Cancer: Principles and Practice of Oncology, 5th ed, p2104) [MeSH];
UMLS CUI (RADLEX) : C0035335;
Origin ID : RID4472;
UMLS CUI : C0035335;
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
Semantic type(s)
UMLS correspondences (same concept)
A malignant tumor arising from the nuclear layer of the retina that is the most common
primary tumor of the eye in children. The tumor tends to occur in early childhood
or infancy and may be present at birth. The majority are sporadic, but the condition
may be transmitted as an autosomal dominant trait. Histologic features include dense
cellularity, small round polygonal cells, and areas of calcification and necrosis.
An abnormal pupil reflex (leukokoria); nystagmus, pathologic; strabismus; and visual
loss represent common clinical characteristics of this condition. (From DeVita et
al., Cancer: Principles and Practice of Oncology, 5th ed, p2104) [MeSH]