Definition : Hereditary disorder transmitted by an autosomal dominant gene and characterized by
multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic
abnormality results in a defect in the osteoclastic activity at the metaphyseal ends
of the bone during the remodeling process in childhood or early adolescence. The metaphyses
develop benign, bony outgrowths often capped by cartilage. A small number undergo
neoplastic transformation. [MeSH];
Hereditary disorder transmitted by an autosomal dominant gene and characterized by
multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic
abnormality results in a defect in the osteoclastic activity at the metaphyseal ends
of the bone during the remodeling process in childhood or early adolescence. The metaphyses
develop benign, bony outgrowths often capped by cartilage. A small number undergo
neoplastic transformation. [MeSH]