Preferred Label : Gallium Ga 68-labeled BNOTA-PRGD2;
NCIt synonyms : 68Ga-BNOTA-PRGD2; 68Ga-p-SCN-Bn-NOTA-PEG3-RGD2;
NCIt related terms : BNOTA-PRGD2 GA-68;
NCIt definition : A radiopharmaceutical agent comprised of a pegylated arginine-glycine-aspartic acid
dimer (PRGD2) labeled with gallium Ga 68, with potential alphaVbeta3 integrin imaging
activity upon positron emission topography (PET) or single photon emission computed
tomography (SPECT). This radiopharmaceutical is prepared by conjugating PRGD2 with
chelator S-2-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid
(BNOTA) which is capable of forming a six-coordinate complex with Ga 68. After intravenous
administration, gallium Ga 68-labeled BNOTA-PRGD2 binds to alphaVbeta3 integrin on
the cell membrane via the cyclic tri-amino acids RGD motif. Upon PET imaging, alphaVbeta3
integrin-expressing tumor cells can be visualized and expression levels can be quantified.
Compared to other radiolabeled RGD-containing peptides, this agent shows increased
affinity to alphaVbeta3 integrin, enhanced tumor uptake as well as improved pharmacokinetics.
alphaVbeta3 integrin is overexpressed on certain tumor cells and tumor endothelial
cells while minimally or not expressed on healthy, normal cells and plays a key role
in angiogenesis, tumor proliferation and survival.;
UNII : QY2HJ2U7WP;
CAS number : 1345968-02-6;
Origin ID : C99904;
UMLS CUI : C3275040;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
