Amonafide Dihydrochloride

Preferred Label : Amonafide Dihydrochloride;

NCIt synonyms : BIDA; Amonafide; Amonafide Hydrochloride; Nafidimide; 1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl); Benzisoquinolinedione;

NCIt definition : The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.;

UNII : 2UAV344O66;

InChIKey : AEMLYYQEBPJIEO-UHFFFAOYSA-N;

CAS number : 150091-68-2;

Drug name : Quinamed;

Molecule name : M-FA-142;

Chemical formula : C16H17N3O2.2ClH;

NSC code : 308847;

Codes from synonyms : CDR0000350223;

Details

Origin ID

C999;

UMLS CUI

C1527333;

Automatic exact mappings (from CISMeF team)
- Horse [LOINC component]
- horses [MeSH Descriptor]
Currated CISMeF NLP mapping
- amonafide [MeSH concept]
- amonafide [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Amonafide [NCIt concept]
is_salt_form_of
- Amonafide [NCIt concept]

Keyword's position in hierarchy(ies) :

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