Preferred Label : Anti-EGFR Monoclonal Antibody Mixture MM-151;
NCIt definition : An oligoclonal therapeutic composed of three fully human monoclonal antibodies targeting
epidermal growth factor receptor (EGFR or ErbB1), with potential antineoplastic activity.
Upon administration of MM-151, the three antibodies bind to distinct, non-overlapping
epitopes of EGFR, thereby preventing the binding of a full range of both high and
low affinity EGFR ligands and inhibiting EGFR-ERK-mediated signaling. This eventually
inhibits tumor cell proliferation in EGFR-overexpressing tumor cells. Furthermore,
multi antibody-antigen bindings cause crosslinking of EGFR and downregulate receptor
signalings that are mediated via heterodimerization of EGFR with other members of
the EGFR family. EGFR, a receptor tyrosine kinase overexpressed in a variety of cancer
cell types, is a key regulator of cancer cell proliferation, apoptosis, invasion,
and metastasis.;
Molecule name : MM-151;
Origin ID : C99899;
UMLS CUI : C3275035;
Currated CISMeF NLP mapping
- MM-151 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- MM-151 [MeSH Supplementary Concept]
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
