NCIt synonyms : L-asparaginase Encapsulated in RBCs; L-asparaginase Encapsulated in Red Blood Cells; Erythrocyte-encapsulated L-asparaginase Suspension;
NCIt definition : A suspension of erythrocytes encapsulating L-asparaginase with potential antineoplastic
activity. Upon administration of eryaspase, L-asparagine is hydrolyzed to L-aspartic
acid and ammonia in plasma, thereby depleting tumor cells of asparagine. Due to low
asparagine synthetase activity in tumor cells, de novo synthesis of asparagine is
suppressed within tumor cells. Shortage of asparagine prevents synthesis of important
proteins necessary for tumor cell growth. Encapsulation of asparaginase in erythrocytes
decreases the immunogenicity of exogenous protein, enhances its circulation time and
may limit toxicity.;
Currated CISMeF NLP mapping