Preferred Label : Oral Aminolevulinic Acid Hydrochloride;
NCIt synonyms : 5-Aminolevulinic Acid Hydrochloride, Oral; Oral 5-ALA; Oral ALA HCl;
NCIt related terms : 5-Aminolevulinic Acid Hydrochloride; 5-ALA fluorescence;
NCIt definition : A powder for an oral solution comprised of the hydrochloride salt of 5-aminolevulinic
acid (ALA) with a potential application for photodynamic therapy. After oral administration,
ALA is converted intracellularly into the photosensitizer protoporphyrin IX (PpIX).
Upon exposure to light of appropriate wavelength (violet to blue range), excited PpIX
emits a characteristic red fluorescence which could facilitate guided resection, and
generates excited singlet oxygen molecules that could kill cells when appropriate
laser dosage is applied. ALA is preferentially taken up by and accumulates in many
types of cancer cells compared to normal, healthy cells. Consequently, cancer cells
can be visualized and can be distinguished from normal, healthy cells.;
Drug name : Gliolan; Gleolan;
NCI Metathesaurus CUI : CL433488;
Origin ID : C99763;
UMLS CUI : C3274910;
Semantic type(s)
- concept_is_in_subset
