Preferred Label : Conditionally Replicative Adenovirus 5/3-delta24;
NCIt synonyms : Conditionally Replicative Adenovirus 3/5-delta; Ad5/3-delta24; CRAd 3/5-delta; CRAd 5/3-delta24;
NCIt definition : A replication competent, oncolytic adenovirus serotype 5 (Ad5) with its knob domain
of fiber protein substituted by that of the serotype 3 (Ad5/3-delta24), with potential
oncolytic activity. Upon administration, oncolytic adenovirus Ad5/3-delta24 binds
to specific Ad3 receptors that are highly expressed on certain tumor cells. This results
in the replication of oncolytic adenovirus Ad5/3-delta24 in tumor cells and induces
tumor cell lysis which may potentially result in the activation of a systemic immune
response against tumor-associated antigens. The Ad5/3-delta24 has a 24 base pair deletion
in constant region 2 of the E1A gene which allows for selective replication in cells
that are defective in the retinoblastoma gene (Rb) or cyclin-dependent kinase inhibitor-2A
(CDKN2A or p16INK4a). As most tumor cells are defective in the Rb/p16 pathway, this
virus selectively replicates in these cells. The replacement of the Ad5 fiber knob,
which mediates viral-cell receptor binding, allows for a Coxsackie-adenovirus receptor
(CAR)-independent infection of tumor cells; CAR expression is often deficient on cancer
cells.;
NCI Metathesaurus CUI : CL433487;
Origin ID : C99762;
UMLS CUI : C3274909;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
