MKL1/RBM15 Fusion Gene

Preferred Label : MKL1/RBM15 Fusion Gene;

NCIt synonyms : MKL1-RBM15 Fusion Gene; MRTFA::RBM15 Fusion Gene; MKL1::RBM15 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(1;22)(p13;q13) which fuses the 5' portion of the MKL1 gene to the 3' portion of the RBM15 gene. This rearrangement is associated with infantile acute megakaryoblastic leukemia.;

NCIt note : Two MKL1/RBM15 transcripts have been described. One transcript can encode a 17 amino acid peptide, while the second one uses an alternative exon and can encode a 25 amino acid protein.;

GenBank Accession Number : AF364037; AF364036;

Details

Origin ID

C99703;

UMLS CUI

C1853687;

Automatic exact mappings (from CISMeF team)
- Myocardin-related transcription factor a [OMIM gene]
- Rna-binding motif protein 15 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
related_to_genetic_biomarker
- MRTFA Gene [NCIt concept]
- RBM15 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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