RBM15/MKL1 Fusion Gene

Preferred Label : RBM15/MKL1 Fusion Gene;

NCIt synonyms : OTT/MAL Fusion Gene; RBM15-MKL1 Fusion Gene; OTT-MAL Fusion Gene; RBM15-MRTFA Fusion Gene; RBM15/MRTFA Fusion Gene; RBM15::MKL1 Fusion Gene; RBM15::MRTFA Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(1;22)(p13;q13) which fuses the 5' portion of the RBM15 gene to the 3' portion of the MKL1 gene. This rearrangement is associated with infantile acute megakaryoblastic leukemia.;

Details

Origin ID

C99701;

UMLS CUI

C3888092;

Automatic exact mappings (from CISMeF team)
- Myocardin-related transcription factor a [OMIM gene]
- Rna-binding motif protein 15 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- RBM15/MKL1 Fusion Protein [NCIt concept]
gene_involved_in_molecular_abnormality
- RBM15-MKL1 Fusion Protein Expression [NCIt concept]
- t(1;22)(p13.3;q13.1) [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1 [NCIt concept]
gene_mapped_to_disease
- Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1 [NCIt concept]
related_to_genetic_biomarker
- MRTFA Gene [NCIt concept]
- RBM15 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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