Preferred Label : pbi-shRNA STMN1 Lipoplex;
NCIt synonyms : pbi-shRNA STMN1 LP;
NCIt related terms : DNA PLASMID (PBI-SHRNA STMN1);
NCIt definition : A proprietary RNA interference construct consisting of bifunctional short hairpin
RNAs (shRNA) against human stathmin 1 (STMN1) encapsulated in the cationic bilamellar
invaginated vesicle lipoplex (LP) with potential antineoplastic activity. pbi-shRNA
STMN1 LP contains 2 stem-loop structures encoded by a plasmid vector. Upon intratumoral
administration, one shRNA unit with a perfectly matched sequence renders the suppression
of STMN1 mRNA translation (mRNA sequestration and cleavage-independent degradation)
while the other unit with an imperfectly matched sequence renders STMN1 mRNA degradation
via RNase H-like cleavage (cleavage-dependent mRNA silencing). The suppression of
STMN1 expression in tumor cells result in a reduction of tumor cell proliferation.
STMN1, a ubiquitous cytosolic phosphoprotein and tubulin modulator that plays a key
role in mitosis, is overexpressed in a variety of tumors and correlates with poor
prognosis.;
UNII : 0TG7ZQ45R5;
NCI Metathesaurus CUI : CL433303;
Origin ID : C99639;
UMLS CUI : C3274843;
Semantic type(s)
- concept_is_in_subset
