Preferred Label : Iodine I 124 Iopofosine;
NCIt synonyms : 124I-NM404; [(124)I]NM404; NM-404 I-124; Iopofosine I 124; 18-(p-[I-124]iodophenyl) Octadecyl Phosphocholine; 124I-CLR1404; I-124-CLR1404; CLR-1404 I-124; I-124-NM404;
NCIt related terms : IOPOFOSINE I-124;
NCIt definition : A radioconjugate composed of the radioisotope iodine I 124 covalently attached to
the alkylphospholipid ether (PLE) analog iopofosine, with potential imaging activity
upon positron emission tomography (PET). Upon administration, iodine I 124 iopofosine
is selectively taken up by tumor cells via membrane lipid rafts and accumulates in
tumor cells. The accumulation of this agent is due to a decreased ability of tumor
cells to metabolize PLEs because certain tumor cells have lower levels of the enzyme
phospholipase-D (PLD), in comparison to normal cells. As tumor cells are unable to
metabolize and eliminate iopofosine, tumor cells can be visualized upon PET imaging.
Lipid rafts, specialized microdomains of plasma membrane, are overexpressed in cancer
cells compared to normal cells. In addition, the radioiodine moiety of this agent
is resistant to de-iodination. PLD is an enzyme found in the cell membrane of normal
cells that degrades phospholipids.;
UNII : 08W354EC17;
CAS number : 873438-87-0;
NCI Metathesaurus CUI : CL433301;
Origin ID : C99636;
UMLS CUI : C5667131;
Semantic type(s)
- concept_is_in_subset
