Preferred Label : Capecitabine Rapidly Disintegrating Tablet;
NCIt synonyms : Capecitabine RDT;
NCIt definition : A rapidly disintegrating film-coated tablet composed of the fluoropyrimidine carbamate
antimetabolite capecitabine with antineoplastic activity. As a prodrug, capecitabine
is converted to 5'-deoxy-5-fluorocytidine (5'-DFCR) by hepatic carboxylesterase and
then to 5'-deoxy-5-fluorouridine (5'-DFUR) by cytidine deaminase and is eventually
activated by thymidine phosphorylase to its cytotoxic moiety, 5-fluorouracil (5-FU);
subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine
monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA
synthesis and cell division by reducing normal thymidine triphosphate production,
while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate
for incorporation into the RNA strand. Capecitabine rapidly disintegrating tablet
(RDT) contains the water insoluble, disintegrating agent crospovidone which very rapidly
disperses and swells in water making this RDT easier to swallow than the traditional
capecitabine tablet.;
NCI Metathesaurus CUI : CL433297;
Origin ID : C99629;
UMLS CUI : C3274836;
- Semantic type(s)
- concept_is_in_subset