LHX4/IGHG1 Fusion Gene

Preferred Label : LHX4/IGHG1 Fusion Gene;

NCIt synonyms : LHX4-IGHG1 Fusion Gene; IGHG1/LHX4 Fusion Gene; LHX4::IGHG1 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(1;14)(q25;q32) which places the LHX4 gene on the 5' side of the coding sequence for the IGHG1 gene. This rearrangement is associated with acute lymphoblastic leukemia.;

NCIt note : This translocation allows the expression of the LHX4 gene to be controlled by the IgG heavy chain promoter, which causes overexpression of the LIM/homeobox protein Lhx4.;

Détails

Origin ID

C99518;

UMLS CUI

C1865797;

Automatic exact mappings (from CISMeF team)
- Igg heavy chain locus [OMIM gene]
- Lim homeobox gene 4 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
related_to_genetic_biomarker
- IGHG1 Gene [NCIt concept]
- LHX4 Gene [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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